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As an avid watcher of the Real Housewives franchise and someone preternaturally drawn to the experiences of older, fabulous women, Im maybe more tuned into The Ozempic Question than is necessarily healthy: Ive spent years watching women navigate thorny issues surrounding toxic beauty standards, of which weight is an essential part

For example, the FDA required that the product label for NATPARA, an approved, injectable parathyroid hormone product targeting PTH1R for the management of hypoparathyroidism include a boxed warning related to the risk of osteosarcoma based on rodent carcinogenicity studies and also implemented a REMS program to ensure patients and prescribers were appropriately counseled on the benefits and risks of the drug

Downstream, this GH stimulation raises circulating insulin-like growth factor-1 (IGF-1), a hormone tied to cellular repair, metabolic regulation, and body composition