compounded tirzepatide vs semaglutide & 2025: Safe Use Guide TrimRX | What is the

Aleksandar Petrov, MD | Updated: July 2026 Last Updated: July 14, 2026 A Retatrutide 4mg dose refers to one of the higher amounts that has been examined in published research on this investigational compound, generally appearing later in a studys range of tested levels

Treatment duration varies based on individual goals, weight loss progress, and recommendations from a healthcare provider

The STEP 1 trial, published in the New England Journal of Medicine, studied once-weekly semaglutide at 2.4mg in adults with overweight or obesity alongside lifestyle intervention

The most common side effects are nausea (reported by 44% of patients in the STEP 1 trial), diarrhea (30%), vomiting (24%), and constipation (24%)