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The N-terminal hexanoyl cap and specific hydrophobic amino acid sequence (Tyr-Ile-Ahx) were engineered specifically to increase lipophilicity and metabolic stability, allowing Dihexa to cross cell membranes and the blood-brain barrier intact in preclinical models

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What "arginate" actually means Peptides synthesized for research use are typically produced as salts, with a counterion attached to improve stability or solubility

Without a priori knowledge of what insults were applied, and in which order, simply observing the final histological lesion renders it impossible to infer the underlying sequence of events nor the initial trigger