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To assess fistula leakage, a separate group of animals received a volume of water intragastrically (1 ml/6 s), either to leaking induction, or to a maximal volume of 20 ml (10-12)

Most patients notice appetite suppression within the first few weeks of Ozempic treatment, though the full effect typically develops over 48 weeks as the dose is gradually titrated from the initial 0.25 mg weekly up to maintenance doses of 0.5 mg, 1 mg, or 2 mg weekly under medical supervision