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However, GLP-1R is expressed in numerous neural populations distributed throughout the CNS (54), and functional mapping of the role of each of these in maintaining energy balance, in effecting GLP-1RAinduced weight loss, and in inducing GLP-1RA side effects remains the subject of intense study

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The PERK-ATF4-CHOP pathway is a central signaling cascade activated in response to ER stress, serving as the cells primary reaction to dysfunction and playing a crucial role in cellular survival

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