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Vitamin B12 is required for creating new red blood cells

This article summarizes what the preclinical work reports, what a regulator would note about the absent human dataset, and the self-reported community adverse-event picture

Further mechanistic studies showed that NNMTi increases intracellular NAD levels and activates the SIRT1 pathway by inhibiting NNMT, thereby suppressing the transcription of adipogenic genes and preventing the maturation of preadipocytes.This research provides a new perspective for understanding the molecular mechanism of adipocyte differentiation, confirms the key role of NNMTi in regulating adipogenesis, and lays a foundation for subsequent obesity intervention studies

This depends on your personal situation, how low your vitamin B12 levels are intracellularly, what kind of medical conditions you have, and how much improvement you get from the B12 shots