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patients should seek urgent medical attention if they experience severe or persistent abdominal pain

When to pause or reverse the taper Red flags that should pause your taper include weight gain exceeding 3% of your lowest weight, significant increase in hunger that interferes with daily functioning, worsening metabolic markers such as rising blood sugar, blood pressure, or lipid levels, return of binge eating patterns or loss-of-control eating episodes, and significant emotional distress related to appetite changes

For the 43% of Americans and 11% of Canadians living with obesity who also experience depression or other mood disorders, the mental health effects of these medications remain largely unknown

Practical Differences: What This Means for Treatment Understanding GLP-1 versus GIP matters when choosing between medications or understanding why one might work better for you than another