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Gastrointestinal: Acute pancreatitis, hemorrhagic and necrotizing pancreatitis sometimes resulting in death, ileus General Disorders and Administration Site Conditions: Allergic reactions: rash and pruritus Hepatobiliary: Elevations of liver enzymes, hyperbilirubinemia, cholestasis, cholecystitis, cholelithiasis requiring cholecystectomy, hepatitis Immune system: Angioedema and anaphylactic reactions Metabolism and nutrition: Dehydration resulting from nausea, vomiting and diarrhea Neoplasms: Medullary thyroid carcinoma Nervous system: Dysgeusia, dizziness Pulmonary: Pulmonary aspiration has occurred in patients receiving GLP-1 receptor agonists undergoing elective surgeries or procedures requiring general anesthesia or deep sedation

MHRA updates guidance for semaglutide prescribers and patients GOV.UK

By this stage, the body has fully adapted to the medication, and weight loss becomes more predictable

Pediatr Nephrol 30:945951