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Furthermore, when combined with anti-PD1 or anti-CTLA4 antibodies, CB-839 promotes the infiltration of effector T cells into tumors and upregulates IFN-associated gene expression, thereby enhancing the antitumor activity of these checkpoint inhibitors [199]

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Case description : A 60-year-old female with a history of estrogen receptor-positive breast cancer presented with significant weight gain following adjuvant endocrine therapy

Simultaneously, skeletal muscle in the elderly demonstrates mitochondrial dysfunction, encompassing diminished mitochondrial biogenesis, compromised oxidative phosphorylation, and an augmented production of reactive oxygen species (ROS), which further intensify endothelial oxidative damage and inflammatory responses (21, 22)