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Phase I detoxification uses cytochrome P450 enzymes to break down toxins, but this process often creates highly reactive, intermediate metabolites that are actually more toxic than the original substance

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This code was added to ICD-10-CM to capture the rapidly growing use of these agents and distinguish them from both oral agents (Z79.84) and insulin (Z79.4)

Autoimmune thyroid disorders Hashimotos thyroiditis Hashimoto thyroiditis is the most common cause of hypothyroidism in iodine-sufficient areas, and it is caused by thyroid gland destruction due to autoimmune disturbance, where the thyroid follicular cells are subjected to death by the effect of CD8 + T cells