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Ask the injector if you can downsize the needle gauge

Tolerability (human reports): Small uncontrolled reports describe NAD+ infusions as generally tolerated, with dose-related flushing and GI effects

Angiogenesis initiation: Early blood vessel formation begins, with increased VEGF expression detectable at injury sites by day 47 (Hsieh et al., 2017)

Potential theoretical concerns include: Unregulated angiogenesis Immune system modulation Tumor growth acceleration under certain conditions Reproductive safety implications Cardiovascular remodeling There is no clinical evidence demonstrating these risks in humans, but comprehensive trials evaluating these endpoints do not exist