Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes
For comparisons with nutraceuticals, two systematic reviews and metaanalyses (each including 8 RCTs) found no significant differences between metformin and myoinositol in metabolic or hormonal outcomes, although myoinositol showed a better safety profile with fewer side effects
Nevertheless, these studies underscore the significant role of natural products in mitigating AD-related pathologies, including neuroinflammation, amyloid aggregation, and cognitive decline
Its most important known metabolic function is to transport long-chain fatty acids to the mitochondria of muscle cells, (including those of the myocardium), where they are oxidized producing energy