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Treatment Protocol Begin with conservative dosing (200-300 mcg daily or 500 mcg twice weekly) and titrate based on response

however, this group reported that alpha-cells with this immature transcriptional profile also exhibited an impaired electrophysiological phenotype and dysregulated exocytosis (73)

Direct stimulation of ghrelin secretion by sympathetic nerves

Previous human trials have shown that subcutaneous administration of oxyntomodulin three times daily for 4 weeks resulted in 1.8 kg greater weight loss than controls [44] as a result of increased activity-related energy expenditure (143 kcal/day) and decreased energy intake (128 kcal) [45]