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The animal studies that form the bulk of cardiovascular evidence typically run 4-6 weeks at most

(2018) found that sertraline causes impaired the steroidogenesis of sex hormones in male rats through the direct inhibition of steroid synthesis and its indirect effects on gene expression, and plasma LH levels and LH/testosterone ratios were significantly increased, potentially triggering compensatory hypogonadism

(7) Tianqi Liu, Ying Liu, Xiaoyu Zhao, Liguo Zhang, Wei Wang, De Bai, Ya Liao, Zhenyuan Wang, Mi Wang, Jiaheng Zhang, Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application, Bioactive Materials, Volume 32, 2024, Pages 502-513 (8) Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK