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Through systematic fractionation of human albumin, Pickart and colleagues isolated a small peptide responsible for the difference, eventually identifying it as a three-amino-acid sequence glycine, histidine, and lysine with an unusually strong affinity for binding copper(II) ions

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Secondary analyses of these studies suggested that weight loss might be the main driver of GLP-1RA efficacy in MASH, supported by the lack of expression of GLP-1 receptors in the human liver 93

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