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Advancing this area will need well-designed, adequately powered RCTs with well-defined responder criteria, together with standardized protocols that adhere to traditional diagnostic principles while confirming reproducibility and regulatory compliance

When bile flow is sluggish or obstructed, it can result in bile stasis, which increases the risk of gallstone formation and inflammation within the biliary system

Waiting until significant loss has occurred reduces potential for recovery

Innovatively, this paper provides the first integrative framework bridging calcium signaling, EV, and ferroptosis under electromagnetic regulation