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The aim of this study was to prove our hypothesis that A-GSH functionalization increases brain endothelial internalization and BBB permeability of polymeric nanoparticles coupled with active agents, namely dopamine and ibuprofen, which have low brain penetration

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instead, a more recent study revealed that melatonin-mediated mPTP inhibition would be highly dependent on the MT1 receptor as mitochondrial protective effects did not occur in the presence of luzindole compound, an MT blocking agent 56

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