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The concentrations achieved in vitro evidently exceeds what is achieved with oral administration, particularly for compounds with limited bioavailability, extensive metabolism, and broad tissue distribution

Additionally, GLP-1R agonists inhibit tau protein hyperphosphorylation, promote the release of brain-derived neurotrophic factor, and reduce neuroinflammatory responses by inhibiting microglial and astrocyte activation [55,56,57]

Tian W, Wang Z, Tang N, Li J, Liu Y, Chu W-F, et al

Tools and Methods for Tracking Progress Therapist Assessments and Reports: Qualified therapists use standardised assessment tools at regular intervals to measure change in specific domains