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Its also even more interesting when you consider that most cases of hypothyroidism (Hashimotos thyroiditis) are also caused by autoimmune disease

4.4 Summary of the integrated testicular-penile pathological axis The mechanisms described above suggest that varicocele may contribute to ED through a multi-level testicularpenile pathological axis centered on inflammation, oxidative stress, vascular dysfunction, smooth muscle remodeling, and neural injury ( Within penile tissue, these systemic signals may induce three major pathological outcomes