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Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo
This cascade activates the ATM-Chk2-p53 axis to execute apoptotic cell death while concurrently imposing cell cycle arrest [58]
Laboratory investigations have revealed FOXO4-DRI's exceptional selectivity for senescent cells, with research demonstrating that more than 80% of senescent cells undergo apoptosis while healthy cells remain unaffected
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