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TLR2 pep-Cys was subsequently conjugated onto orid-liposome through reversible Michael addition reaction, through a cysteine residue between maleimide and thiol group

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& Mayerle, J

In addition, the ultrasmall nanotrap can capture endogenous iron and target it for transport to the TAMs inside the tumor, and iron was released from the nanotrap when exposed to lysosomal acidity and intracellular H 2 O 2 and generate oxidative stress thereby reprograming the TAMs to activated M1 TAMs and inducing immune response and ultimately inhibiting tumor growth (34)