As an important mode of intercellular communication, EVs play a critical role in the pathogenesis of NAFLD and its actions in NAFLD were reviewed recently [103]
Adjustments can be made as needed
Consider these evidence-based dietary strategies: Eat small, frequent, low-fat meals that are easier to digest Limit sugar alcohols (sorbitol, mannitol, xylitol) found in sugar-free products, which have known laxative effects Gradually increase soluble fiber through foods like oatmeal and psyllium supplements, which can help bulk stools Avoid excessive insoluble fiber from raw vegetables and whole grains during acute episodes Stay adequately hydrated with water and electrolyte-containing beverages to prevent dehydration Avoid spicy, greasy, or very high-fiber foods during episodes of diarrhea Medication dosing may require adjustment
These effects are more likely at higher doses, particularly above 3,000 mg per day, and taking supplements with food can help reduce gastrointestinal discomfort
