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Kynurenine is predominantly metabolized to the N -methyl-d-aspartate (NMDA) receptor agonist quinolinic acid (QUIN) in the inflammatory state, contributing to the accumulation of glutamate in the extracellular space, leading to changes in network connectivity associated with depression, fatigue and cognitive impairment

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PubMed CrossRef Vidarsdottir S, de Leeuw van Weenen JE, Frlich M, et al

Even insured patients often face $100$500 monthly copays despite having active coverage