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In men, the restrictions are due to the potential for reversible male infertility, testicular problems, and the risks of neurodevelopmental conditions in children born to men taking valproate in the 3 months before conception

In fact, cobalamin deficiency is a common cause of metabolic encephalopathy, one of a number of forms of encephalopathy associated with a primary disease (such as FIP) that causes interference with normal brain function and blood-brain barrier mechanisms