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c) Trypsin cleavage of P 11 shows the location of the single arginine, which is found as the C-terminal unit of the tetrapeptide fragment

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This biological link is supported by common underlying pathways, such as hepatic and systemic insulin resistance, atherogenic lipid profiles, hypertension, and increased expression of pro-atherogenic, pro-coagulant, and pro-inflammatory factors [75]