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In clinical trials [2], the most common side effects were mild digestive issues, including: nausea diarrhoea vomiting constipation These symptoms were dose-related, usually mild to moderate, and often improved when the dose was increased more slowly

Pharmacol Ther 197:103121

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Even though the pharmaceutical industry appears to have largely withdrawn its interest in pursuing the H3R as an anti-obesity target (189), work endures to optimize H3R ligands and explore their potential to influence food intake and body weight, and H3R antagonists/inverse agonists continue to be proposed for the treatment of obesity (190, 191)