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If translation is initiated from the first start codon, then Glr1 is encoded with a mitochondrial matrix targeting sequence, while translation from the second start codon leads to a shorter cytosolic protein (Outten and Culotta, 2004)

Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sanchdev V, Hazen SL, Vichinsky EP, Morris SM, Gladwin MT (2005) Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension and mortality in sickle cell disease

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