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3.5 Inflammation-induced impairment of synaptic plasticity Overexpression of inflammatory cytokines reduces neurotrophic factor levels, thereby impairing synaptic plasticity and exacerbating neural circuit dysfunction and emotional dysregulation

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In addition to the aforementioned remodelling of the metabolome in fatigue-associated diseases, including long COVID, acylcarnitines have emerged as important modulators of CNS function [29]: In both mice and humans, different classes of acylcarnitines have been found to be altered in either mouse models of depression or humans with MDD, with associations to symptom severity and also treatment response, as reviewed by Liu et al

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