Clinical trial endpoints often measure weight change at 26 weeks, reflecting the time needed for the full therapeutic trajectory to unfold
Plus, there's the contamination risk of mixing things up on your own, outside the clean rooms that pharma normally uses
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Niclosamide can readily revert to its most stable form, and so reduce its solubility However, if, and when, precipitated or present as a particulate material, (e.g., micronized or surfactant- or protein- or polymer-stabilized microparticles as observed in our provisional patent work (48)), the amount of niclosamide in aqueous solution is determined by the nature of the crystalline or amorphous material that the local aqueous solution is in equilibrium with, or is moving towards