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GLP-1 receptor agonists e.g., semaglutide, liraglutide commonly cause gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during dose escalation, less common risks include pancreatitis, gallbladder disease, and hypoglycemia mainly with insulin sulfonylureas

Instead, angle the needle so that it's touching the inside wall of the glass vial

Both medications target incretin pathways, but their receptor activation profiles create distinct physiological effects