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Pressure Overload Induced Cardiac Remodeling Cardiac remodeling, a process associated with conditions such as hypertension, MI and valvular disease, involves changes in the hearts structure and function in response to chronic stress and injury [80,81,82]

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As researchers delve deeper into the genetic underpinnings of this disorder, genetic testing emerges as a beacon of hope, offering insights into diagnosis, management, and potential treatment strategies

We also consider the effect of these molecules on other obesity-related complications [glycaemia in people with T2D and on liver fat content in people with MASLD/metabolic dysfunction-associated steatohepatitis (MASH, previously known as non-alcoholic steatohepatitis)] and we discuss the potential clinical implications and challenges that the new era in obesity pharmacotherapy will bring