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The only clinically relevant difference between treatments was the higher frequency of gastrointestinal related adverse events with IcoSema versus icodec or semaglutide alone, which can be mitigated by appropriate dosing recommendations for IcoSema, as discussed above

This can help individuals eat less, leading to an average weight loss of 15% when combined with diet and exercise

If the device has been refrigerated, allow it to reach room temperature for the period specified in your trial instructions before injecting, as this may reduce discomfort

Preliminary data and mechanistic understanding both suggest positive results, but the medical community rightly demands completed trials before making definitive claims