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It contains salicylate, which is chemically related to aspirin

Peripherally acting anti-obesity medicines with evidence for use in older adults Orlistat Weight loss trials None of the XENDOS trial participants were older adults, and hence the results from this study may not be applicable to an ageing population, although as the drug works peripherally there is no reason to suggest reduced efficacy or safety in elderly patients

The measurable difference is body composition (fat-to-muscle ratio), not scale weight

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