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The main ongoing challenge is maintaining adequate nutrition despite reduced appetite

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The prevalence of MetS in PWS adults and children is 34% and 7% respectively (172, 174), potentially contributing to the reported early mortality rates in the PWS population (171, 175)

Potential muscle-related effects include: Improved body composition Reduced visceral fat Mild increases in lean mass In a randomized, placebo-controlled study in HIV-infected adults with abdominal fat accumulation, daily subcutaneous tesamorelin for six months significantly reduced visceral adipose tissue compared with placebo and also increased trunk and total lean body mass, indicating improved overall body composition beyond just weight changes