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Additionally, paeoniflorin was reported to reduce the expression of the L-tryptophan-catabolizing enzyme tryptophan-2,3-dioxygenase in the liver of stress-induced depressive mice, thereby increasing the 5-hydroxytryptamine/tryptophan ratio and decreasing the kynurenine/tryptophan ratio (Liang et al., 2023)

The racemic form was more widely used clinically in Europe and Japan in the 1950s to 1960s despite the early recognition that the various forms of LA are not bioequivalent

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A 2019 review suggested that certain chemical UV filters may have negative effects for water sources, fish health, and food chains worldwide