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By increasing free iron through ferritin autophagy, a selective autophagy mechanism that targets ferritin, ferritin might encourage ferroptosis ( 3.1.2 ROS imbalance plays an important role in ferroptosis Lipid peroxidation is the fundamental root cause of ferroptosis, and since lipids make up the majority of cell membranes, they are also the dominating targets of ROS

Based on this evidence, it is recommended that long-term pharmacological management prioritize the optimization of treatment timing, formulation of personalized dosing regimens, and implementation of systematic efficacy monitoring and adverse reaction assessment protocols, to maximize therapeutic benefits while minimizing potential risks

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Afterwards, the correction equation of hepatic CL int was established for in vitro metabolism experiments (Poulin and Haddad, 2013)