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Their advantageous properties, including low molecular weight, minimal immunogenicity, facile chemical synthesis, robust tissue penetration, and an expansive target scope, position them as compelling alternatives to antibodies for addressing the cardinal limitations of PROTACs, namely poor selectivity, off-target toxicity, and inadequate delivery efficiency (Fig

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A detailed review of literature has found increased oxidative stress in acute as well as chronic infections of the ear, nose, and sinuses and the rationale for adding an antioxidant to the therapy (126)