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a) Memoria Metablica: El seguimiento efectuado hasta la actualidad de los participantes de DCCT, permiti demostrar menor mortalidad general y cardiovascular tarda en los pacientes pertenecientes al grupo tratado inicialmente en forma intensivo por un periodo de 7 aos, al final de este periodo los pacientes tratados en forma convencional cambiaron a tratamiento intensivo y desde entonces se manejan todos de la misma forma

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However, only several studies also monitored cardiometabolic effects alongside cognitive assessment (Table 1), and there exist reports of exceeding the 1 g/kg concentration range until the desired neuroprotective effect has been reached (47)

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