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When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before

This is when the body is adjusting to slower digestion and reduced food intake

How Long Does It Take for GLP-1 to Suppress Appetite GLP-1 medications, like Semaglutide, work by mimicking a natural hormone in your body that helps control hunger

The licensed medical group structure matters more than most review content acknowledges