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Its hard to tell exactly what is happening from this dataset, so we need follow-up studies to help us understand whether the differences seen here hold up in randomized trials. It is unclear how much if any of the benefits observed among GLP-1 users in this study and prior investigations are due to an antitumor effect, but Fuemmeler outlined three potential pathways

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Several metabolic adaptations make it challenging to sustain weight loss long-term, including hormonal changes, increased food noise, and the energy gap. Shifts in Hunger Hormones Hunger and satiety are partially driven by hormones released from the gut to the hypothalamus (a region of the forebrain)

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