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For those patients who express concerns about injections or lack confidence with self-injections, it would be appropriate for the primary practitioner to demonstrate the ease with which these devices can be used

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The recommended approach is to discontinue semaglutide, allow a washout period of at least 2-3 weeks (given semaglutide approximately one-week half-life), and then begin retatrutide titration from the standard 1 mg starting dose

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