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Absolute deficiency occur up to 6% of those aged 60 years and older, whereas marginal deficiency occur in close to 20% of patients in later life ( Pernicious anemia is an autoimmune gastritis resulting from the destruction of gastric parietal cells and consequent impairment of intrinsic factors secretion to bind the ingested vitamin B12

Nitric oxide signaling connects the three systems, regulating blood flow and inflammatory responses across muscular, digestive, and neural tissue simultaneously