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CLOCK and BMAL1 the positive transcriptional activators in the core circadian loop have been shown to regulate DNA damage response pathways and to interact directly with telomere-binding proteins

Some of the studies described in the review based on animal models so far have shown beneficial effects in reducing asthma symptoms by activating nociception NOP1, bombesin BRS-3 and somatostatin SST4 receptors, or blocking the NPY-Y1 receptor

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