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Phentermine can lose its appetite-suppressing effect over time as your body builds tolerance to stimulants, and that doesnt mean youve failed

The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )

Here's what over 100 published studies actually show