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Roughly 20 to 30% of users, particularly those with severe chronic degeneration, report minimal improvement

Between games, daily cryotherapy sessions lasting 15 minutes help maintain inflammation control

Furthermore, its tolerability profile, which includes weight gain, edema/fluid retention, fractures, and (rarely) bladder cancer in long-term use, could hinder its potential repositioning for depression [173]

However, with IBD-current biologic therapies, all these mean some patients primary non-responders, experience a loss of response, intolerance or side effects, defining the urgent unmet need for novel treatments (13, 14)