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Thermogenesis increases slightly

Clinicians do not need to proceed in a linear algorithm or a hierarchy from first-line to sixth-line treatments described in the previous guideline

3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)