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The 2026 Cell Reports Medicine analysis found that GLP-1 receptor agonist treatment did upregulate certain mitochondrial proteins including SIRT5 in skeletal muscle compared to calorie restriction alone

The STEP-1 extension trial followed patients who had lost weight on semaglutide and then switched to placebo

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We set it as an absolute difference of 0.1% between groups, which is more conservative than the difference found in previous trials 20