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Amylin has several characteristics of a satiating hormone: 1) it is released after food ingestion ( via central mechanisms (61)

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Previous research has shown that immuno-metabolic dysregulations map more consistently to symptoms of the atypical spectrum characterized by altered energy intake/output (in particular the reversed neurovegetative symptoms of hyperphagia, hypersomnia with leaden paralysis and fatigue) [2] and symptoms of anhedonia [33]

Pathway 4 - Exercise-Mimetic Signaling MOTS-c activates many of the same pathways as exercise: better endurance, better metabolic flexibility, more stress tolerance