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The review contextualised native GLP-1 as the reference molecule for the entire dual GIP/GLP-1 receptor agonist research field including tirzepatide (approved) and novel triple agonists targeting GLP-1R, GIPR, and GCGR simultaneously confirming native GLP-1s ongoing research importance as the pharmacological anchor of this rapidly expanding compound class

M., Muoz-Garach, A., lvarez-Bermdez, M

Following laboratory testing, the drugmaker said it uncovered "significant levels" of an impurity in the compounded products, which results from a chemical reaction between tirzepatide -- a GIP/GLP-1 receptor agonist indicated for type 2 diabetes, weight loss, and obstructive sleep apnea -- and B12, often listed on product labels as methylcobalamin, hydroxocobalamin, or cyanocobalamin