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PMID: 34234567 Davis, S., et al

CagriSema , Novo Nordisks co-formulation of semaglutide 2.4mg and the long-acting amylin analogue cagrilintide, demonstrated 22.7% body weight reduction in the REDEFINE-1 Phase 3 trial substantially exceeding standalone semaglutide and positioning Novo Nordisk to defend GLP-1 market leadership against tirzepatides superior weight loss profile

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The contraindication applies regardless of whether 5-amino-1MQ is stacked with tirzepatide the thyroid cancer risk is specific to the GLP-1 agonist component